| 1. Jornada | 25.07.2021 | Pumas UNAM [Sub 18] | - | Atlas Guadalajara [Sub 18] | 1:2 | ||||
| 2. Jornada | 31.07.2021 | CF Monterrey [Sub 18] | - | Pumas UNAM [Sub 18] | 1:2 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 18] | - | Atlético San Luis [Sub 18] | 1:1 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 | ||||
| 10. Jornada | 25.09.2021 | UANL Tigres [Sub 18] | - | Pumas UNAM [Sub 18] | 6:0 | ||||
| 12. Jornada | 03.10.2021 | CF América [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | ||||
| 13. Jornada | 17.10.2021 | Pumas UNAM [Sub 18] | - | FC Juárez [Sub 18] | 2:0 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 18] | - | Club Tijuana [Sub 18] | 2:2 | ||||
| 16. Jornada | 30.10.2021 | CF Pachuca [Sub 18] | - | Pumas UNAM [Sub 18] | 1:0 | ||||
| 11. Jornada | 04.11.2021 | Pumas UNAM [Sub 18] | - | Santos Laguna [Sub 18] | 0:1 | ||||
| 17. Jornada | 07.11.2021 | Pumas UNAM [Sub 18] | - | Cruz Azul [Sub 18] | 2:2 |
México