| 1. Jornada | 24.07.2021 | CF Pachuca [Sub 18] | - | Club León [Sub 18] | 5:1 |  |
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| 3. Jornada | 05.08.2021 | Gallos Blancos [Sub 18] | - | Club León [Sub 18] | 0:1 | ||||
| 7. Jornada | 28.08.2021 | Club León [Sub 18] | - | CF América [Sub 18] | 0:1 | ||||
| 10. Jornada | 25.09.2021 | Atlas Guadalajara [Sub 18] | - | Club León [Sub 18] | 2:3 | ||||
| 14. Jornada | 20.10.2021 | Club León [Sub 18] | - | Pumas UNAM [Sub 18] | 2:1 | ||||
| 16. Jornada | 31.10.2021 | Deportivo Toluca [Sub 18] | - | Club León [Sub 18] | 1:3 | |
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| 11. Jornada | 03.11.2021 | Cruz Azul [Sub 18] | - | Club León [Sub 18] | 2:3 |
México