4. Jornada | 16.08.2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
6. Jornada | 22.08.2021 | Club León | - | Santos Laguna | 1:1 | ||||
8. Jornada | 11.09.2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
13. Jornada | 17.10.2021 | CF Pachuca | - | Santos Laguna | 1:1 | ||||
14. Jornada | 20.10.2021 | CF América | - | Santos Laguna | 2:1 | ||||
11. Jornada | 05.11.2021 | Pumas UNAM | - | Santos Laguna | 0:3 |