| 1. Jornada | 16.07.2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
| 2. Jornada | 19.07.2022 | Guaireña FC | - | Sportivo Ameliano | 3:1 |  |
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| 3. Jornada | 24.07.2022 | Club Olimpia | - | Guaireña FC | 2:1 | |
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| 4. Jornada | 29.07.2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
| 5. Jornada | 05.08.2022 | Resistencia SC | - | Guaireña FC | 1:2 | |
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| 6. Jornada | 14.08.2022 | Guaireña FC | - | 12 de Octubre de Itauguá | 2:1 | |
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| 7. Jornada | 20.08.2022 | Sol de América | - | Guaireña FC | 2:0 | ||||
| 8. Jornada | 26.08.2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 10.09.2022 | Guaireña FC | - | Libertad | 4:0 | ||||
| 11. Jornada | 15.09.2022 | Cerro Porteño | - | Guaireña FC | 2:2 | |
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| 13. Jornada | 23.09.2022 | Sportivo Ameliano | - | Guaireña FC | 2:0 | |
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| 14. Jornada | 02.10.2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 15. Jornada | 05.10.2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | ||||
| 19. Jornada | 27.10.2022 | Club Nacional | - | Guaireña FC | 3:0 | |
Paraguay