| 15. Jornada | 09.10.2021 | Newell's Old Boys | - | Vélez Sarsfield | 1:2 |  |
|||
| 16. Jornada | 16.10.2021 | Gimnasia de La Plata | - | Newell's Old Boys | 1:0 | ||||
| 17. Jornada | 21.10.2021 | Newell's Old Boys | - | Aldosivi | 0:0 | ||||
| 18. Jornada | 25.10.2021 | Sarmiento de Junín | - | Newell's Old Boys | 2:1 | ||||
| 19. Jornada | 31.10.2021 | Newell's Old Boys | - | Independiente | 1:0 | ||||
| 20. Jornada | 08.11.2021 | Newell's Old Boys | - | Unión de Santa Fe | 1:0 | ||||
| 21. Jornada | 21.11.2021 | Arsenal de Sarandí | - | Newell's Old Boys | 3:1 | ||||
| 22. Jornada | 24.11.2021 | Newell's Old Boys | - | Central Córdoba SdE | 1:0 | ||||
| 23. Jornada | 30.11.2021 | Boca Juniors | - | Newell's Old Boys | 0:0 | ||||
| 24. Jornada | 07.12.2021 | Newell's Old Boys | - | Banfield | 0:0 | ||||
| 25. Jornada | 12.12.2021 | San Lorenzo | - | Newell's Old Boys | 3:2 |
Paraguay