| 1. Jornada | 25.07.2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
| 2. Jornada | 03.08.2021 | Atlético San Luis | - | Gallos Blancos | 1:1 | ||||
| 8. Jornada | 11.09.2021 | Puebla FC | - | Atlético San Luis | 2:2 | ||||
| 14. Jornada | 22.09.2021 | FC Juárez | - | Atlético San Luis | 1:0 | ||||
| 13. Jornada | 17.10.2021 | Atlético San Luis | - | CF América | 0:1 | ||||
| 16. Jornada | 01.11.2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 5. Jornada | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 | ||||
| 17. Jornada | 08.11.2021 | Santos Laguna | - | Atlético San Luis | 0:0 |
México