| 1. Jornada | 10.02.2022 | Patronato de Paraná II | - | Argentinos Juniors II | 0:1 | ||||
| 2. Jornada | 15.02.2022 | Argentinos Juniors II | - | Newell's Old Boys II | 1:1 | ||||
| 3. Jornada | 19.02.2022 | Racing Club II | - | Argentinos Juniors II | 0:4 |  |
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| 5. Jornada | 03.03.2022 | Gimnasia de La Plata II | - | Argentinos Juniors II | 1:0 | ||||
| 6. Jornada | 12.03.2022 | Argentinos Juniors II | - | Defensa y Justicia II | 0:1 | ||||
| 7. Jornada | 20.03.2022 | Argentinos Juniors II | - | Vélez Sarsfield II | 3:3 | ||||
| 8. Jornada | 04.04.2022 | Banfield II | - | Argentinos Juniors II | 1:0 | ||||
| 9. Jornada | 09.04.2022 | River Plate II | - | Argentinos Juniors II | 0:0 | ||||
| 10. Jornada | 14.04.2022 | Argentinos Juniors II | - | Talleres de Córdoba II | 5:0 | ||||
| 11. Jornada | 21.04.2022 | Atlético Tucumán II | - | Argentinos Juniors II | 2:1 | ||||
| 13. Jornada | 02.05.2022 | Platense II | - | Argentinos Juniors II | 1:1 | ||||
| 14. Jornada | 05.05.2022 | Argentinos Juniors II | - | Unión de Santa Fe II | 4:0 |
Argentina