| 1. Jornada | 04.02.2022 | Sol de América | - | Club Nacional | 0:0 | ||||
| 2. Jornada | 14.02.2022 | Club Nacional | - | Cerro Porteño | 2:3 |  |
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| 3. Jornada | 19.02.2022 | Resistencia SC | - | Club Nacional | 3:1 |  |
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| 8. Jornada | 04.04.2022 | Club Nacional | - | Sportivo Ameliano | 2:1 | ||||
| 11. Jornada | 21.04.2022 | Club Nacional | - | Guaireña FC | 3:1 | ||||
| 18. Jornada | 13.06.2022 | Club Nacional | - | Tacuary | 3:0 |
Paraguay