| 1. Jornada | 06.02.2022 | Independiente Petrolero | - | Always Ready | 1:2 |  |
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| 2. Jornada | 12.02.2022 | Always Ready | - | Royal Pari | 2:2 |  |
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| 3. Jornada | 19.02.2022 | Always Ready | - | Real Tomayapo | 0:1 | ||||
| 4. Jornada | 27.02.2022 | Bolívar | - | Always Ready | 3:0 | ||||
| 5. Jornada | 06.03.2022 | Always Ready | - | Jorge Wilstermann | 0:0 | ||||
| 6. Jornada | 12.03.2022 | Real Santa Cruz | - | Always Ready | 0:1 | ||||
| 9. Jornada | 16.04.2022 | Always Ready | - | Independiente Petrolero | 1:1 | |
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| 10. Jornada | 20.04.2022 | Royal Pari | - | Always Ready | 5:1 | |
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| 12. Jornada | 01.05.2022 | Always Ready | - | Bolívar | 1:2 | |
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| 13. Jornada | 08.05.2022 | Always Ready | - | Real Santa Cruz | 5:0 | |
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| 14. Jornada | 12.05.2022 | Jorge Wilstermann | - | Always Ready | 1:0 | ||||
| 15. Jornada | 15.05.2022 | Always Ready | - | Blooming | 3:0 | |
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| 16. Jornada | 22.05.2022 | Universitario de Vinto | - | Always Ready | 2:1 |
Bolivia
