| 5. Jornada | 27.07.2022 | Atlético San Luis | - | Cruz Azul | 0:0 |  |
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| 6. Jornada | 31.07.2022 | Puebla FC | - | Atlético San Luis | 0:0 | ||||
| 16. Jornada | 04.08.2022 | FC Juárez | - | Atlético San Luis | 1:1 | ||||
| 9. Jornada | 19.08.2022 | Atlético San Luis | - | Pumas UNAM | 3:2 | ||||
| 10. Jornada | 22.08.2022 | Atlético San Luis | - | Deportivo Toluca | 1:0 | ||||
| 11. Jornada | 29.08.2022 | Santos Laguna | - | Atlético San Luis | 4:1 | ||||
| 12. Jornada | 02.09.2022 | Atlético San Luis | - | Club Tijuana | 0:0 | |
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| 13. Jornada | 07.09.2022 | CF América | - | Atlético San Luis | 3:0 | ||||
| 14. Jornada | 12.09.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:3 | ||||
| 15. Jornada | 19.09.2022 | Atlético San Luis | - | CF Pachuca | 1:2 | ||||
| 17. Jornada | 02.10.2022 | Atlético San Luis | - | UANL Tigres | 0:3 |
México