| 3. Jornada | 08.08.2021 | Pumas UNAM [Sub 20] | - | Atlético San Luis [Sub 20] | 5:3 |  |
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| 4. Jornada | 14.08.2021 | Pumas UNAM [Sub 20] | - | Gallos Blancos [Sub 20] | 1:4 | ||||
| 5. Jornada | 17.08.2021 | Club Necaxa [Sub 20] | - | Pumas UNAM [Sub 20] | 1:1 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 20] | - | Puebla FC [Sub 20] | 1:3 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca [Sub 20] | - | Pumas UNAM [Sub 20] | 2:2 | ||||
| 8. Jornada | 12.09.2021 | Pumas UNAM [Sub 20] | - | Deportivo Guadalajara [Sub 20] | 1:2 | ||||
| 10. Jornada | 25.09.2021 | UANL Tigres [Sub 20] | - | Pumas UNAM [Sub 20] | 2:1 | ||||
| 15. Jornada | 24.10.2021 | Pumas UNAM [Sub 20] | - | Club Tijuana [Sub 20] | 4:0 |
Paraguay