| 8. Jornada | 26.02.2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 9. Jornada | 05.03.2022 | Deportivo Guadalajara [] | - | Atlas Guadalajara [] | 2:2 | ||||
| 10. Jornada | 12.03.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 0:2 | ||||
| 11. Jornada | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 16. Jornada | 23.04.2022 | Atlas Guadalajara [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 17. Jornada | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 |
México