| 3. Jornada | 22.01.2022 | Club Necaxa [Sub 16] | - | Cruz Azul [Sub 16] | 2:1 |  |
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| 4. Jornada | 29.01.2022 | FC Juárez [Sub 16] | - | Club Necaxa [Sub 16] | 1:1 | |
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| 8. Jornada | 26.02.2022 | Club Necaxa [Sub 16] | - | Gallos Blancos [Sub 16] | 2:0 | |
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| 12. Jornada | 26.03.2022 | Puebla FC [Sub 16] | - | Club Necaxa [Sub 16] | 2:3 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [Sub 16] | - | CF América [Sub 16] | 2:1 | ||||
| 14. Jornada | 09.04.2022 | CF Pachuca [Sub 16] | - | Club Necaxa [Sub 16] | 1:2 |
México