| 1. Jornada | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Jornada | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
| 3. Jornada | 22.01.2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
| 7. Jornada | 18.02.2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Jornada | 26.02.2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
| 9. Jornada | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
| 10. Jornada | 12.03.2022 | UANL Tigres [] | - | Club León [] | 1:1 | ||||
| 12. Jornada | 26.03.2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 | ||||
| 13. Jornada | 02.04.2022 | Mazatlán FC [] | - | Club León [] | 0:3 | ||||
| 14. Jornada | 06.04.2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 |
México