| 1. Jornada | 07.01.2022 | Puebla FC [Sub 18] | - | CF América [Sub 18] | 0:1 | ||||
| 2. Jornada | 15.01.2022 | UANL Tigres [Sub 18] | - | Puebla FC [Sub 18] | 1:0 | ||||
| 3. Jornada | 21.01.2022 | Puebla FC [Sub 18] | - | Club Tijuana [Sub 18] | 1:1 | ||||
| 4. Jornada | 06.02.2022 | Gallos Blancos [Sub 18] | - | Puebla FC [Sub 18] | 3:1 | ||||
| 6. Jornada | 18.02.2022 | Puebla FC [Sub 18] | - | CF Monterrey [Sub 18] | 1:1 | ||||
| 7. Jornada | 26.02.2022 | Deportivo Guadalajara [Sub 18] | - | Puebla FC [Sub 18] | 3:0 | ||||
| 10. Jornada | 13.03.2022 | Atlético San Luis [Sub 18] | - | Puebla FC [Sub 18] | 1:0 |  |
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| 12. Jornada | 03.04.2022 | Deportivo Toluca [Sub 18] | - | Puebla FC [Sub 18] | 0:1 | ||||
| 14. Jornada | 16.04.2022 | Club León [Sub 18] | - | Puebla FC [Sub 18] | 5:4 | ||||
| 15. Jornada | 19.04.2022 | CF Pachuca [Sub 18] | - | Puebla FC [Sub 18] | 3:0 |
México