| 3. Jornada | 22.01.2022 | Club Tijuana [] | - | Atlético San Luis [] | 5:0 | ||||
| 6. Jornada | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 9. Jornada | 05.03.2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 | ||||
| 11. Jornada | 19.03.2022 | Deportivo Guadalajara [] | - | Club Tijuana [] | 3:0 | ||||
| 12. Jornada | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 13. Jornada | 02.04.2022 | Club Tijuana [] | - | Atlas Guadalajara [] | 0:1 | ||||
| 14. Jornada | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 | ||||
| 15. Jornada | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Jornada | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 17. Jornada | 30.04.2022 | Club Tijuana [] | - | Mazatlán FC [] | 4:0 | ||||
| 18. Jornada | 07.05.2022 | CF Monterrey [] | - | Club Tijuana [] | 1:0 |  |
Estados Unidos