| 11. Jornada | 10.09.2021 | Newell's Old Boys II | - | River Plate II | 0:2 | ||||
| 12. Jornada | 17.09.2021 | Lanús II | - | Newell's Old Boys II | 0:2 | ||||
| 17. Jornada | 18.10.2021 | Newell's Old Boys II | - | Aldosivi II | 1:0 | ||||
| 19. Jornada | 29.10.2021 | Newell's Old Boys II | - | Independiente II | 1:0 | ||||
| 20. Jornada | 05.11.2021 | Newell's Old Boys II | - | Unión de Santa Fe II | 1:2 | ||||
| 22. Jornada | 24.11.2021 | Newell's Old Boys II | - | Central Córdoba SdE II | 1:1 | ||||
| 23. Jornada | 30.11.2021 | Boca Juniors II | - | Newell's Old Boys II | 1:0 | ||||
| 24. Jornada | 06.12.2021 | Newell's Old Boys II | - | Banfield II | 2:0 |  |
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| 25. Jornada | 10.12.2021 | San Lorenzo II | - | Newell's Old Boys II | 2:1 |
Argentina