| 1. Jornada | 24.07.2021 | Havre AC | - | Guingamp | 0:0 | ||||
| 5. Jornada | 23.08.2021 | AJ Auxerre | - | Guingamp | 1:2 | ||||
| 6. Jornada | 28.08.2021 | Guingamp | - | AC Ajaccio | 1:1 | ||||
| 7. Jornada | 11.09.2021 | Paris FC | - | Guingamp | 0:1 | ||||
| 8. Jornada | 18.09.2021 | Chamois Niortais | - | Guingamp | 2:0 | ||||
| 13. Jornada | 23.10.2021 | Guingamp | - | Nîmes Olympique | 3:1 | ||||
| 14. Jornada | 30.10.2021 | Toulouse | - | Guingamp | 2:2 | ||||
| 15. Jornada | 06.11.2021 | Guingamp | - | Bastia | 2:3 | ||||
| 16. Jornada | 20.11.2021 | Pau FC | - | Guingamp | 2:0 | ||||
| 17. Jornada | 03.12.2021 | Guingamp | - | Dijon FCO | 3:2 | ||||
| 18. Jornada | 11.12.2021 | Caen | - | Guingamp | 2:0 |  |
|||
| 19. Jornada | 21.12.2021 | Guingamp | - | USL Dunkerque | 2:1 |
Bélgica