| 3. Jornada | 28.02.2022 | Deportes Iquique | - | Deportes Temuco | 1:0 |  |
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| 4. Jornada | 09.03.2022 | Puerto Montt | - | Deportes Iquique | 0:0 |  |
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| 5. Jornada | 16.03.2022 | Deportes Iquique | - | CD Magallanes | 1:1 | |
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| 6. Jornada | 22.03.2022 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 7. Jornada | 03.04.2022 | Deportes Iquique | - | Santa Cruz | 2:2 | |
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| 8. Jornada | 09.04.2022 | Fernández Vial | - | Deportes Iquique | 0:0 | ||||
| 18. Jornada | 02.07.2022 | Deportes Iquique | - | Santiago Wanderers | 2:1 | ||||
| 20. Jornada | 16.07.2022 | Deportes Temuco | - | Deportes Iquique | 3:2 | |
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| 21. Jornada | 26.07.2022 | Deportes Iquique | - | Puerto Montt | 1:1 | ||||
| 23. Jornada | 09.08.2022 | Deportes Iquique | - | Santiago Morning | 3:1 | ||||
| 26. Jornada | 31.08.2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 28. Jornada | 12.09.2022 | Rangers | - | Deportes Iquique | 0:2 | ||||
| 29. Jornada | 25.09.2022 | Deportes Iquique | - | Universidad de Concepción | 1:2 | ||||
| 31. Jornada | 10.10.2022 | Deportes Iquique | - | Barnechea | 0:2 |
Argentina