| 5. Jornada | 12.08.2018 | Libertad | - | Guaraní | 3:0 |  |
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| 6. Jornada | 19.08.2018 | Guaraní | - | Sol de América | 2:1 | ||||
| 7. Jornada | 25.08.2018 | 3 de Febrero | - | Guaraní | 2:1 | |
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| 8. Jornada | 02.09.2018 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 9. Jornada | 09.09.2018 | General Díaz | - | Guaraní | 3:1 |  |
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| 13. Jornada | 07.10.2018 | Guaraní | - | Cerro Porteño | 0:1 | ||||
| 15. Jornada | 21.10.2018 | Club Nacional | - | Guaraní | 0:0 | ||||
| 20. Jornada | 24.11.2018 | Guaraní | - | General Díaz | 0:2 | |
Argentina
Chile