| 3. Jornada | 22.01.2022 | Atlas Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 2:2 | ||||
| 5. Jornada | 05.02.2022 | CF Monterrey [Sub 16] | - | Club León [Sub 16] | 0:1 | ||||
| 6. Jornada | 12.02.2022 | UANL Tigres [Sub 16] | - | CF Monterrey [Sub 16] | 1:0 | ||||
| 8. Jornada | 26.02.2022 | CF Monterrey [Sub 16] | - | Atlético San Luis [Sub 16] | 5:1 |  |
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| 10. Jornada | 12.03.2022 | Mazatlán FC [Sub 16] | - | CF Monterrey [Sub 16] | 2:3 | |
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| 17. Jornada | 30.04.2022 | Club León [Sub 16] | - | CF Monterrey [Sub 16] | 1:2 | ||||
| 18. Jornada | 07.05.2022 | CF Monterrey [Sub 16] | - | Club Tijuana [Sub 16] | 3:1 |
México