| 1. Jornada | 12.02.2021 | San Lorenzo II | - | Arsenal de Sarandí II | 3:0 |  |
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| 2. Jornada | 19.02.2021 | Colón de Santa Fe II | - | San Lorenzo II | 1:1 | ||||
| 3. Jornada | 26.02.2021 | San Lorenzo II | - | Central Córdoba SdE II | 2:1 | ||||
| 4. Jornada | 05.03.2021 | San Lorenzo II | - | Huracán II | 2:2 | ||||
| 5. Jornada | 12.03.2021 | Banfield II | - | San Lorenzo II | 2:1 | |
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| 6. Jornada | 19.03.2021 | San Lorenzo II | - | Aldosivi II | 0:1 | ||||
| 7. Jornada | 29.03.2021 | Estudiantes II | - | San Lorenzo II | 4:1 | ||||
| 8. Jornada | 02.04.2021 | San Lorenzo II | - | Rosario Central II | 0:0 | ||||
| 9. Jornada | 09.04.2021 | Platense II | - | San Lorenzo II | 2:0 | ||||
| 10. Jornada | 16.04.2021 | San Lorenzo II | - | Argentinos Juniors II | 2:2 | ||||
| 11. Jornada | 23.04.2021 | River Plate II | - | San Lorenzo II | 2:1 | ||||
| 12. Jornada | 30.04.2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 13. Jornada | 07.05.2021 | Racing Club II | - | San Lorenzo II | 1:2 |
Argentina