| 7. Jornada | 20.08.2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
| 9. Jornada | 30.08.2021 | San Lorenzo II | - | Patronato de Paraná II | 2:2 |  |
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| 10. Jornada | 05.09.2021 | Platense II | - | San Lorenzo II | 1:1 | ||||
| 12. Jornada | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 19. Jornada | 31.10.2021 | San Lorenzo II | - | Godoy Cruz II | 0:1 | ||||
| 20. Jornada | 05.11.2021 | Vélez Sarsfield II | - | San Lorenzo II | 2:0 | ||||
| 23. Jornada | 27.11.2021 | San Lorenzo II | - | Sarmiento de Junín II | 3:1 | ||||
| 24. Jornada | 06.12.2021 | Independiente II | - | San Lorenzo II | 1:0 |
Argentina