| 1. Jornada | 07.02.2022 | Cerro Porteño | - | Sportivo Ameliano | 3:2 | ||||
| 9. Jornada | 10.04.2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
| 10. Jornada | 18.04.2022 | Cerro Porteño | - | Libertad | 4:0 | ||||
| 11. Jornada | 22.04.2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 16. Jornada | 15.05.2022 | Sol de América | - | Cerro Porteño | 2:1 | ||||
| 20. Jornada | 22.06.2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 | ||||
| 21. Jornada | 26.06.2022 | Libertad | - | Cerro Porteño | 1:0 | ||||
| 22. Jornada | 02.07.2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay