| 1. Jornada | 25.07.2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Jornada | 01.08.2021 | Vorskla Poltava | - | Rukh Lviv | 2:0 |  |
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| 3. Jornada | 07.08.2021 | Rukh Lviv | - | NK Veres | 2:1 | |
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| 4. Jornada | 15.08.2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | ||||
| 5. Jornada | 21.08.2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 6. Jornada | 29.08.2021 | Rukh Lviv | - | FK Lviv | 1:0 | |
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| 7. Jornada | 11.09.2021 | Rukh Lviv | - | Zorya Lugansk | 1:1 | ||||
| 8. Jornada | 17.09.2021 | Desna Chernigov | - | Rukh Lviv | 1:0 | ||||
| 9. Jornada | 25.09.2021 | Rukh Lviv | - | Dinamo Kiev | 0:2 | |
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| 13. Jornada | 31.10.2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 | ||||
| 14. Jornada | 06.11.2021 | Chernomorets Odessa | - | Rukh Lviv | 4:3 | ||||
| 15. Jornada | 20.11.2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 | ||||
| 16. Jornada | 28.11.2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Jornada | 04.12.2021 | Rukh Lviv | - | Vorskla Poltava | 0:0 | |
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| 18. Jornada | 11.12.2021 | NK Veres | - | Rukh Lviv | 1:1 |
Ucrania