| 1. Jornada | 06.02.2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
| 2. Jornada | 13.02.2022 | Guaraní | - | Sol de América | 0:1 |  |
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| 3. Jornada | 19.02.2022 | Cerro Porteño | - | Guaraní | 2:0 | ||||
| 5. Jornada | 07.03.2022 | 12 de Octubre de Itauguá | - | Guaraní | 1:3 | ||||
| 6. Jornada | 13.03.2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
| 7. Jornada | 20.03.2022 | Libertad | - | Guaraní | 2:0 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | ||||
| 9. Jornada | 10.04.2022 | Sportivo Ameliano | - | Guaraní | 0:1 | |
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| 10. Jornada | 17.04.2022 | Guaraní | - | Club Nacional | 0:1 | ||||
| 14. Jornada | 09.05.2022 | Guaraní | - | Cerro Porteño | 1:2 |  |
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| 17. Jornada | 22.05.2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
| 18. Jornada | 14.06.2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Jornada | 20.06.2022 | Tacuary | - | Guaraní | 0:2 | ||||
| 20. Jornada | 23.06.2022 | Guaraní | - | Sportivo Ameliano | 1:1 | ||||
| 21. Jornada | 27.06.2022 | Club Nacional | - | Guaraní | 0:1 | |
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| 22. Jornada | 04.07.2022 | Guaraní | - | Club Olimpia | 0:2 |
Paraguay