| 7. Jornada | 11.09.2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Jornada | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 9. Jornada | 25.09.2021 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 10. Jornada | 02.10.2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 |  |
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| 13. Jornada | 29.10.2021 | Spartak Trnava | - | FK Senica | 2:1 |  |
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| 14. Jornada | 06.11.2021 | FK Senica | - | Zlaté Moravce | 1:2 | |
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| 15. Jornada | 20.11.2021 | FC DAC 1904 | - | FK Senica | 1:0 | ||||
| 16. Jornada | 30.11.2021 | FK Senica | - | MŠK Žilina | 2:2 | |
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| 17. Jornada | 04.12.2021 | FK Senica | - | Tatran Liptovský Mikuláš | 1:0 | ||||
| 18. Jornada | 11.12.2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Jornada | 18.12.2021 | FK Senica | - | AS Trenčín | 1:0 | |
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| 20. Jornada | 12.02.2022 | Slovan Bratislava | - | FK Senica | 5:0 | ||||
| 21. Jornada | 20.02.2022 | FK Senica | - | ŠKF Sereď | 1:2 | ||||
| 22. Jornada | 26.02.2022 | MFK Zemplín Michalovce | - | FK Senica | 0:1 |
República Checa
Eslovaquia