| 1. Jornada | 06.02.2022 | Guaireña FC | - | Guaraní | 0:0 | ||||
| 2. Jornada | 12.02.2022 | Guaireña FC | - | Club Olimpia | 1:3 | ||||
| 6. Jornada | 14.03.2022 | Guaireña FC | - | 12 de Octubre de Itauguá | 0:0 | ||||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 |  |
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| 13. Jornada | 02.05.2022 | Club Olimpia | - | Guaireña FC | 1:0 | ||||
| 14. Jornada | 08.05.2022 | Guaireña FC | - | Sol de América | 2:1 |  |
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| 15. Jornada | 12.05.2022 | Cerro Porteño | - | Guaireña FC | 0:0 |  |
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| 16. Jornada | 14.05.2022 | Guaireña FC | - | Resistencia SC | 0:0 | ||||
| 20. Jornada | 24.06.2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Jornada | 27.06.2022 | Sportivo Ameliano | - | Guaireña FC | 2:2 | |
Paraguay