| 1. Jornada | 20.07.2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 4. Jornada | 03.08.2021 | Rosario Central | - | Aldosivi | 1:2 | ||||
| 5. Jornada | 07.08.2021 | Sarmiento de Junín | - | Rosario Central | 1:0 | ||||
| 6. Jornada | 15.08.2021 | Rosario Central | - | Independiente | 1:2 | ||||
| 9. Jornada | 29.08.2021 | Central Córdoba SdE | - | Rosario Central | 2:4 | ||||
| 12. Jornada | 20.09.2021 | Rosario Central | - | San Lorenzo | 1:0 | ||||
| 13. Jornada | 25.09.2021 | Talleres de Córdoba | - | Rosario Central | 4:1 | ||||
| 14. Jornada | 03.10.2021 | Rosario Central | - | Argentinos Juniors | 0:1 |  |
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| 16. Jornada | 15.10.2021 | Rosario Central | - | Patronato de Paraná | 3:2 | ||||
| 19. Jornada | 31.10.2021 | Unión de Santa Fe | - | Rosario Central | 3:1 |  |
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| 20. Jornada | 05.11.2021 | Defensa y Justicia | - | Rosario Central | 3:0 | |
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| 24. Jornada | 05.12.2021 | CA Lanús | - | Rosario Central | 2:2 |
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