| 1. Jornada | 17.01.2020 | Guaraní | - | San Lorenzo | 0:0 | ||||
| 2. Jornada | 27.01.2020 | Guaraní | - | Cerro Porteño | 1:0 | ||||
| 3. Jornada | 01.02.2020 | 12 de Octubre de Itauguá | - | Guaraní | 1:3 |  |
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| 4. Jornada | 09.02.2020 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 5. Jornada | 16.02.2020 | Club Nacional | - | Guaraní | 1:2 | ||||
| 7. Jornada | 02.03.2020 | Sportivo Luqueño | - | Guaraní | 0:3 | ||||
| 8. Jornada | 08.03.2020 | Guaraní | - | Sol de América | 1:1 | ||||
| 9. Jornada | 24.07.2020 | Guaireña FC | - | Guaraní | 1:1 | ||||
| 10. Jornada | 28.07.2020 | Guaraní | - | General Díaz | 0:0 | ||||
| 11. Jornada | 02.08.2020 | Libertad | - | Guaraní | 1:3 | ||||
| 6. Jornada | 06.08.2020 | Guaraní | - | River Plate | 3:0 | ||||
| 13. Jornada | 13.08.2020 | Cerro Porteño | - | Guaraní | 1:0 |  |
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| 18. Jornada | 05.09.2020 | Guaraní | - | Sportivo Luqueño | 3:0 | ||||
| 19. Jornada | 12.09.2020 | Sol de América | - | Guaraní | 1:2 | ||||
| 20. Jornada | 20.09.2020 | Guaraní | - | Guaireña FC | 0:0 | ||||
| 21. Jornada | 28.09.2020 | General Díaz | - | Guaraní | 0:1 | ||||
| 22. Jornada | 05.10.2020 | Guaraní | - | Libertad | 1:1 |  |
Argentina