| 1. Jornada | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Jornada | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 3. Jornada | 31.01.2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 4. Jornada | 04.02.2021 | Montevideo Wanderers | - | Boston River | 2:2 | ||||
| 5. Jornada | 06.02.2021 | Deportivo Maldonado | - | Montevideo Wanderers | 1:1 | ||||
| 6. Jornada | 10.02.2021 | Montevideo Wanderers | - | Rentistas | 3:2 | ||||
| 7. Jornada | 13.02.2021 | Cerro Largo | - | Montevideo Wanderers | 1:3 | ||||
| 8. Jornada | 17.02.2021 | Liverpool | - | Montevideo Wanderers | 2:1 | ||||
| 9. Jornada | 21.02.2021 | Montevideo Wanderers | - | Peñarol | 0:1 | ||||
| 10. Jornada | 27.02.2021 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
| 11. Jornada | 06.03.2021 | Montevideo Wanderers | - | Montevideo City Torque | 2:8 |  |
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| 12. Jornada | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 | ||||
| 13. Jornada | 21.03.2021 | Montevideo Wanderers | - | Progreso | 3:0 |  |
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| 14. Jornada | 25.03.2021 | Fénix | - | Montevideo Wanderers | 3:3 | |
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| 15. Jornada | 29.03.2021 | Montevideo Wanderers | - | CA Cerro | 1:1 |
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