| 2. Jornada | 01.08.2021 | FK Mariupol | - | Desna Chernigov | 1:2 | ||||
| 3. Jornada | 07.08.2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 |  |
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| 5. Jornada | 22.08.2021 | FK Mariupol | - | Zorya Lugansk | 3:4 | ||||
| 6. Jornada | 28.08.2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Jornada | 12.09.2021 | Kolos Kovalivka | - | FK Mariupol | 1:3 | ||||
| 9. Jornada | 25.09.2021 | FK Oleksandriya | - | FK Mariupol | 2:1 | ||||
| 10. Jornada | 01.10.2021 | FK Mariupol | - | Rukh Lviv | 0:2 | ||||
| 11. Jornada | 16.10.2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 12. Jornada | 23.10.2021 | NK Veres | - | FK Mariupol | 2:0 | ||||
| 13. Jornada | 30.10.2021 | FK Mariupol | - | Dinamo Kiev | 2:3 |  |
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| 14. Jornada | 06.11.2021 | FC Mynai | - | FK Mariupol | 0:2 | ||||
| 16. Jornada | 26.11.2021 | FK Mariupol | - | FK Lviv | 0:1 | ||||
| 17. Jornada | 05.12.2021 | Desna Chernigov | - | FK Mariupol | 3:3 | ||||
| 18. Jornada | 10.12.2021 | FK Mariupol | - | SK Dnipro-1 | 0:3 |
Ucrania