| 1. Jornada | 26.07.2021 | Vorskla Poltava | - | SK Dnipro-1 | 2:2 |  |
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| 2. Jornada | 31.07.2021 | Chernomorets Odessa | - | SK Dnipro-1 | 0:3 | ||||
| 3. Jornada | 07.08.2021 | SK Dnipro-1 | - | FK Mariupol | 2:1 |  |
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| 4. Jornada | 14.08.2021 | Desna Chernigov | - | SK Dnipro-1 | 2:1 | ||||
| 5. Jornada | 21.08.2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | |
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| 6. Jornada | 28.08.2021 | Metalist 1925 Kharkiv | - | SK Dnipro-1 | 1:2 | ||||
| 7. Jornada | 11.09.2021 | Shakhtar Donetsk | - | SK Dnipro-1 | 2:0 | ||||
| 8. Jornada | 18.09.2021 | SK Dnipro-1 | - | NK Veres | 1:0 | ||||
| 10. Jornada | 02.10.2021 | FK Lviv | - | SK Dnipro-1 | 0:1 | ||||
| 11. Jornada | 16.10.2021 | SK Dnipro-1 | - | Kolos Kovalivka | 2:0 | ||||
| 12. Jornada | 24.10.2021 | Dinamo Kiev | - | SK Dnipro-1 | 2:0 | ||||
| 13. Jornada | 01.11.2021 | SK Dnipro-1 | - | FC Mynai | 4:0 | ||||
| 14. Jornada | 07.11.2021 | Inhulets Petrove | - | SK Dnipro-1 | 0:1 | ||||
| 16. Jornada | 27.11.2021 | SK Dnipro-1 | - | Vorskla Poltava | 5:1 | ||||
| 17. Jornada | 06.12.2021 | SK Dnipro-1 | - | Chernomorets Odessa | 3:1 | |
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| 18. Jornada | 10.12.2021 | FK Mariupol | - | SK Dnipro-1 | 0:3 |
Ucrania