| 3. Jornada | 08.08.2021 | Vorskla Poltava | - | FK Lviv | 4:1 |  |
|||
| 4. Jornada | 15.08.2021 | FK Lviv | - | FK Oleksandriya | 1:1 | ||||
| 5. Jornada | 23.08.2021 | FK Lviv | - | Inhulets Petrove | 1:2 |  |
|||
| 6. Jornada | 29.08.2021 | Rukh Lviv | - | FK Lviv | 1:0 | ||||
| 7. Jornada | 13.09.2021 | NK Veres | - | FK Lviv | 1:0 | |
|||
| 8. Jornada | 19.09.2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | |
|||
| 9. Jornada | 26.09.2021 | FC Mynai | - | FK Lviv | 1:2 | |
|||
| 11. Jornada | 16.10.2021 | FK Lviv | - | Dinamo Kiev | 1:4 | ||||
| 12. Jornada | 23.10.2021 | Chernomorets Odessa | - | FK Lviv | 1:1 | ||||
| 13. Jornada | 31.10.2021 | Kolos Kovalivka | - | FK Lviv | 0:1 | |
|||
| 14. Jornada | 07.11.2021 | FK Lviv | - | Desna Chernigov | 0:2 | ||||
| 15. Jornada | 20.11.2021 | FK Lviv | - | Zorya Lugansk | 2:1 | |
|||
| 16. Jornada | 26.11.2021 | FK Mariupol | - | FK Lviv | 0:1 | |
|||
| 17. Jornada | 03.12.2021 | Shakhtar Donetsk | - | FK Lviv | 6:1 | |
|||
| 18. Jornada | 11.12.2021 | FK Lviv | - | Vorskla Poltava | 1:1 | |
Ucrania