2. Jornada | 26.07.2021 | Cerro Porteño | - | Libertad | 1:1 | ||||
4. Jornada | 08.08.2021 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
5. Jornada | 15.08.2021 | Club Olimpia | - | Cerro Porteño | 0:3 | ||||
11. Jornada | 04.10.2021 | Libertad | - | Cerro Porteño | 0:2 | ||||
13. Jornada | 25.10.2021 | Guaireña FC | - | Cerro Porteño | 0:2 |