| 1. Jornada | 08.01.2022 | Gallos Blancos [Sub 16] | - | CF América [Sub 16] | 0:3 | ||||
| 2. Jornada | 15.01.2022 | CF América [Sub 16] | - | Pumas UNAM [Sub 16] | 1:0 | ||||
| 3. Jornada | 09.02.2022 | CF América [Sub 16] | - | Puebla FC [Sub 16] | 1:0 | ||||
| 9. Jornada | 05.03.2022 | Cruz Azul [Sub 16] | - | CF América [Sub 16] | 3:2 | ||||
| 13. Jornada | 03.04.2022 | Club Necaxa [Sub 16] | - | CF América [Sub 16] | 2:1 | ||||
| 15. Jornada | 16.04.2022 | Deportivo Toluca [Sub 16] | - | CF América [Sub 16] | 1:2 | ||||
| 16. Jornada | 23.04.2022 | CF América [Sub 16] | - | CF Pachuca [Sub 16] | 2:0 | ||||
| 18. Jornada | 07.05.2022 | CF América [Sub 16] | - | FC Juárez [Sub 16] | 3:3 |
México