| 1. Jornada | 08.08.2021 | RC Strasbourg | - | Angers | 0:2 | ||||
| 2. Jornada | 15.08.2021 | Angers | - | Lyon | 3:0 | ||||
| 3. Jornada | 22.08.2021 | Girondins de Burdeos | - | Angers | 1:1 | ||||
| 4. Jornada | 29.08.2021 | Angers | - | Rennes | 2:0 | ||||
| 5. Jornada | 12.09.2021 | Stade Brestois 29 | - | Angers | 1:1 | ||||
| 6. Jornada | 19.09.2021 | Angers | - | Nantes | 1:4 | ||||
| 7. Jornada | 22.09.2021 | Angers | - | Marsella | 0:0 | ||||
| 8. Jornada | 26.09.2021 | Troyes | - | Angers | 1:1 | ||||
| 9. Jornada | 03.10.2021 | Angers | - | FC Metz | 3:2 | ||||
| 10. Jornada | 15.10.2021 | París Saint-Germain | - | Angers | 2:1 | ||||
| 11. Jornada | 22.10.2021 | Saint-Étienne | - | Angers | 2:2 | ||||
| 12. Jornada | 31.10.2021 | Angers | - | Niza | 1:2 | ||||
| 19. Jornada | 22.12.2021 | Montpellier | - | Angers | 4:1 |
Francia