| 1. Jornada | 24.07.2021 | Havre AC | - | Guingamp | 0:0 |  |
|||
| 2. Jornada | 31.07.2021 | Guingamp | - | Valenciennes FC | 1:1 |  |
|
||
| 3. Jornada | 07.08.2021 | Grenoble Foot 38 | - | Guingamp | 0:0 | ||||
| 4. Jornada | 14.08.2021 | Guingamp | - | Amiens SC | 0:2 | ||||
| 5. Jornada | 23.08.2021 | AJ Auxerre | - | Guingamp | 1:2 | ||||
| 6. Jornada | 28.08.2021 | Guingamp | - | AC Ajaccio | 1:1 | ||||
| 16. Jornada | 20.11.2021 | Pau FC | - | Guingamp | 2:0 | ||||
| 17. Jornada | 03.12.2021 | Guingamp | - | Dijon FCO | 3:2 | ||||
| 18. Jornada | 11.12.2021 | Caen | - | Guingamp | 2:0 | ||||
| 20. Jornada | 08.01.2022 | Valenciennes FC | - | Guingamp | 1:1 | ||||
| 21. Jornada | 15.01.2022 | Guingamp | - | Grenoble Foot 38 | 0:0 | ||||
| 23. Jornada | 05.02.2022 | Guingamp | - | AJ Auxerre | 1:1 | |
|||
| 24. Jornada | 12.02.2022 | AC Ajaccio | - | Guingamp | 0:1 | |
|||
| 25. Jornada | 19.02.2022 | Guingamp | - | Paris FC | 1:1 |
Brasil