| 3. Jornada | 07.08.2021 | CF América [Sub 20] | - | Puebla FC [Sub 20] | 3:3 | ||||
| 4. Jornada | 13.08.2021 | Puebla FC [Sub 20] | - | UANL Tigres [Sub 20] | 2:1 |  |
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| 5. Jornada | 18.08.2021 | Club Tijuana [Sub 20] | - | Puebla FC [Sub 20] | 3:0 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM [Sub 20] | - | Puebla FC [Sub 20] | 1:3 | |
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| 7. Jornada | 27.08.2021 | Puebla FC [Sub 20] | - | Gallos Blancos [Sub 20] | 0:1 | ||||
| 8. Jornada | 10.09.2021 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:2 | ||||
| 11. Jornada | 28.09.2021 | Atlas Guadalajara [Sub 20] | - | Puebla FC [Sub 20] | 3:3 | |
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| 15. Jornada | 23.10.2021 | Puebla FC [Sub 20] | - | Club León [Sub 20] | 2:1 |  |
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| 16. Jornada | 29.10.2021 | FC Juárez [Sub 20] | - | Puebla FC [Sub 20] | 1:1 | |
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| 17. Jornada | 05.11.2021 | Puebla FC [Sub 20] | - | Deportivo Toluca [Sub 20] | 0:3 |
México