| 2. Jornada | 10.02.2021 | Club Nacional | - | Sol de América | 1:0 | ||||
| 7. Jornada | 10.03.2021 | Club Olimpia | - | Club Nacional | 1:4 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 |  |
|||
| 10. Jornada | 02.04.2021 | Club Nacional | - | Guaraní | 2:0 | ||||
| 11. Jornada | 11.04.2021 | Sol de América | - | Club Nacional | 1:2 | ||||
| 12. Jornada | 17.04.2021 | Club Nacional | - | Sportivo Luqueño | 1:0 | ||||
| 13. Jornada | 26.04.2021 | Libertad | - | Club Nacional | 1:1 | ||||
| 14. Jornada | 01.05.2021 | Club Nacional | - | Guaireña FC | 1:3 | ||||
| 16. Jornada | 18.05.2021 | Club Nacional | - | Club Olimpia | 2:1 |
Paraguay