| 1. Jornada | 18.07.2021 | River Plate | - | Colón de Santa Fe | 1:2 |  |
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| 8. Jornada | 27.08.2021 | River Plate | - | Aldosivi | 2:0 | ||||
| 11. Jornada | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 | ||||
| 12. Jornada | 20.09.2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 13. Jornada | 26.09.2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Jornada | 03.10.2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 16. Jornada | 18.10.2021 | River Plate | - | San Lorenzo | 3:1 | ||||
| 17. Jornada | 22.10.2021 | Talleres de Córdoba | - | River Plate | 0:2 |  |
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| 18. Jornada | 26.10.2021 | River Plate | - | Argentinos Juniors | 3:0 | ||||
| 19. Jornada | 01.11.2021 | Estudiantes | - | River Plate | 1:1 | |
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| 20. Jornada | 08.11.2021 | River Plate | - | Patronato de Paraná | 5:0 | ||||
| 21. Jornada | 22.11.2021 | Platense | - | River Plate | 0:1 | ||||
| 22. Jornada | 26.11.2021 | River Plate | - | Racing Club | 4:0 | ||||
| 23. Jornada | 28.11.2021 | Rosario Central | - | River Plate | 2:2 | ||||
| 24. Jornada | 06.12.2021 | River Plate | - | Defensa y Justicia | 2:3 | ||||
| 25. Jornada | 11.12.2021 | Atlético Tucumán | - | River Plate | 1:1 |
Paraguay