| 1. Jornada | 13.07.2019 | Guaraní | - | River Plate | 1:3 |  |
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| 2. Jornada | 21.07.2019 | Libertad | - | Guaraní | 1:0 | |
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| 3. Jornada | 28.07.2019 | Guaraní | - | Sportivo Luqueño | 1:3 | ||||
| 4. Jornada | 05.08.2019 | Cerro Porteño | - | Guaraní | 2:2 | ||||
| 5. Jornada | 12.08.2019 | Guaraní | - | Deportivo Santaní | 2:1 | |
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| 6. Jornada | 18.08.2019 | Deportivo Capiatá | - | Guaraní | 1:2 | ||||
| 7. Jornada | 25.08.2019 | Guaraní | - | San Lorenzo | 3:1 | |
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| 9. Jornada | 15.09.2019 | Sol de América | - | Guaraní | 0:1 | |
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| 10. Jornada | 22.09.2019 | Guaraní | - | Club Olimpia | 1:1 | |
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| 11. Jornada | 25.09.2019 | Club Nacional | - | Guaraní | 0:2 | ||||
| 12. Jornada | 29.09.2019 | River Plate | - | Guaraní | 0:1 | ||||
| 13. Jornada | 05.10.2019 | Guaraní | - | Libertad | 1:1 |  |
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| 14. Jornada | 21.10.2019 | Sportivo Luqueño | - | Guaraní | 1:0 | ||||
| 15. Jornada | 27.10.2019 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 16. Jornada | 31.10.2019 | Deportivo Santaní | - | Guaraní | 2:1 | ||||
| 18. Jornada | 10.11.2019 | San Lorenzo | - | Guaraní | 0:0 | ||||
| 17. Jornada | 24.11.2019 | Guaraní | - | Deportivo Capiatá | 2:1 | |
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| 19. Jornada | 28.11.2019 | General Díaz | - | Guaraní | 0:3 | |
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| 21. Jornada | 08.12.2019 | Club Olimpia | - | Guaraní | 2:2 | |
Uruguay