| 16. Jornada | 17.07.2021 | FK Smorgon | - | Energetik-BGU Minsk | 2:2 |  |
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| 17. Jornada | 25.07.2021 | FK Smorgon | - | FK Isloch Minsk | 1:2 | |
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| 18. Jornada | 31.07.2021 | FK Smorgon | - | FK Slaviya Mozyr | 0:2 | ||||
| 19. Jornada | 15.08.2021 | FK Smorgon | - | Shakhter Soligorsk | 2:2 | |
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| 20. Jornada | 21.08.2021 | FK Smorgon | - | Rukh Brest | 1:1 | ||||
| 22. Jornada | 12.09.2021 | FK Smorgon | - | BATE Borisov | 1:3 | ||||
| 24. Jornada | 26.09.2021 | FK Smorgon | - | Dinamo Minsk | 0:5 | ||||
| 25. Jornada | 02.10.2021 | Torpedo-BelAZ Zhodino | - | FK Smorgon | 7:1 | ||||
| 26. Jornada | 16.10.2021 | FK Smorgon | - | FK Vitebsk | 2:0 | |
 |
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| 27. Jornada | 23.10.2021 | FK Slutsk | - | FK Smorgon | 2:1 | ||||
| 28. Jornada | 07.11.2021 | FK Smorgon | - | Dinamo Brest | 1:1 | ||||
| 29. Jornada | 20.11.2021 | FK Gomel | - | FK Smorgon | 0:0 | ||||
| 30. Jornada | 28.11.2021 | FK Smorgon | - | FK Minsk | 1:0 |
Bielorrusia