| 1. Jornada | 17.07.2010 | Tacuary | - | Club Rubio Ñu | 0:0 |  |
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| 2. Jornada | 24.07.2010 | Libertad | - | Tacuary | 3:0 |  |
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| 4. Jornada | 07.08.2010 | Guaraní | - | Tacuary | 1:0 | ||||
| 5. Jornada | 15.08.2010 | Tacuary | - | Cerro Porteño | 0:1 | |
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| 6. Jornada | 21.08.2010 | Sport Colombia | - | Tacuary | 1:3 |  |
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| 7. Jornada | 28.08.2010 | Tacuary | - | Sol de América | 1:1 | |
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| 8. Jornada | 05.09.2010 | Sportivo Trinidense | - | Tacuary | 1:1 | ||||
| 9. Jornada | 11.09.2010 | Tacuary | - | Sportivo Luqueño | 0:3 | ||||
| 10. Jornada | 19.09.2010 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 11. Jornada | 25.09.2010 | Club Nacional | - | Tacuary | 1:0 | |
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| 12. Jornada | 02.10.2010 | Club Rubio Ñu | - | Tacuary | 1:2 | ||||
| 20. Jornada | 21.11.2010 | Sportivo Luqueño | - | Tacuary | 3:1 | |
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| 21. Jornada | 27.11.2010 | Club Olimpia | - | Tacuary | 2:1 | ||||
| 22. Jornada | 03.12.2010 | Tacuary | - | Club Nacional | 1:2 |
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