| 1. Jornada | 27.07.2021 | Cruz Azul | - | Mazatlán FC | 0:2 | ||||
| 2. Jornada | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Jornada | 15.08.2021 | Club León | - | Mazatlán FC | 3:0 | ||||
| 5. Jornada | 18.08.2021 | Deportivo Toluca | - | Mazatlán FC | 2:2 | ||||
| 7. Jornada | 28.08.2021 | Mazatlán FC | - | Atlético San Luis | 2:2 | ||||
| 8. Jornada | 12.09.2021 | CF América | - | Mazatlán FC | 2:0 | ||||
| 9. Jornada | 19.09.2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
| 14. Jornada | 20.10.2021 | Puebla FC | - | Mazatlán FC | 2:0 | ||||
| 15. Jornada | 23.10.2021 | Mazatlán FC | - | Gallos Blancos | 2:1 |
Estados Unidos