| 7. Jornada | 29.08.2021 | Santos Laguna [Sub 18] | - | FC Juárez [Sub 18] | 0:0 | ||||
| 8. Jornada | 10.09.2021 | Club Tijuana [Sub 18] | - | Santos Laguna [Sub 18] | 3:0 | ||||
| 10. Jornada | 26.09.2021 | Santos Laguna [Sub 18] | - | CF Monterrey [Sub 18] | 2:0 | ||||
| 12. Jornada | 02.10.2021 | Santos Laguna [Sub 18] | - | Mazatlán FC [Sub 18] | 3:0 |
México