| 1. Jornada | 23.07.2021 | Club Necaxa [Sub 20] | - | Santos Laguna [Sub 20] | 3:0 | ||||
| 2. Jornada | 01.08.2021 | Santos Laguna [Sub 20] | - | Cruz Azul [Sub 20] | 1:0 | ||||
| 5. Jornada | 18.08.2021 | Santos Laguna [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:1 | ||||
| 7. Jornada | 29.08.2021 | Santos Laguna [Sub 20] | - | FC Juárez [Sub 20] | 3:1 | ||||
| 8. Jornada | 11.09.2021 | Club Tijuana [Sub 20] | - | Santos Laguna [Sub 20] | 2:2 |  |
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| 14. Jornada | 15.09.2021 | CF América [Sub 20] | - | Santos Laguna [Sub 20] | 0:1 |
México