| 1. Jornada | 12.03.2022 | Almere City FC [Sub 21] | - | FC Groningen [Sub 21] | 4:3 | ||||
| 2. Jornada | 19.03.2022 | FC Groningen [Sub 21] | - | ADO Den Haag [Sub 21] | 1:0 | ||||
| 3. Jornada | 02.04.2022 | NAC Breda [Sub 21] | - | FC Groningen [Sub 21] | 1:1 | ||||
| 4. Jornada | 09.04.2022 | Feyenoord [Sub 21] | - | FC Groningen [Sub 21] | 1:0 | ||||
| 5. Jornada | 23.04.2022 | FC Groningen [Sub 21] | - | Willem II [Sub 21] | 1:2 | ||||
| 6. Jornada | 30.04.2022 | NEC Nijmegen [Sub 21] | - | FC Groningen [Sub 21] | 0:4 | ||||
| 7. Jornada | 14.05.2022 | FC Groningen [Sub 21] | - | PEC Zwolle [Sub 21] | 3:1 |  |
Noruega