| 1. Jornada | 05.02.2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
| 3. Jornada | 21.02.2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 5. Jornada | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 6. Jornada | 13.03.2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
| 4. Jornada | 26.03.2022 | Sol de América | - | Club Olimpia | 0:1 | ||||
| 8. Jornada | 02.04.2022 | Resistencia SC | - | Club Olimpia | 2:1 | ||||
| 9. Jornada | 09.04.2022 | Club Olimpia | - | Club Nacional | 1:2 |  |
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| 10. Jornada | 16.04.2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:0 | ||||
| 12. Jornada | 24.04.2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
| 14. Jornada | 08.05.2022 | Libertad | - | Club Olimpia | 1:0 | |
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| 15. Jornada | 12.05.2022 | Club Olimpia | - | Sol de América | 1:0 | ||||
| 17. Jornada | 22.05.2022 | Club Olimpia | - | Cerro Porteño | 0:4 | ||||
| 18. Jornada | 14.06.2022 | Sportivo Ameliano | - | Club Olimpia | 1:4 |  |
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| 20. Jornada | 23.06.2022 | Club Nacional | - | Club Olimpia | 1:1 |
Colombia