| 2. Jornada | 31.07.2021 | Chernomorets Odessa | - | SK Dnipro-1 | 0:3 |  |
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| 4. Jornada | 16.08.2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | ||||
| 5. Jornada | 21.08.2021 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 | ||||
| 6. Jornada | 27.08.2021 | Chernomorets Odessa | - | FK Oleksandriya | 2:2 | ||||
| 7. Jornada | 12.09.2021 | FC Mynai | - | Chernomorets Odessa | 2:2 | ||||
| 8. Jornada | 19.09.2021 | Zorya Lugansk | - | Chernomorets Odessa | 3:0 | ||||
| 9. Jornada | 27.09.2021 | Chernomorets Odessa | - | Inhulets Petrove | 1:1 | |
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| 13. Jornada | 01.11.2021 | Vorskla Poltava | - | Chernomorets Odessa | 0:0 | ||||
| 14. Jornada | 06.11.2021 | Chernomorets Odessa | - | Rukh Lviv | 4:3 | ||||
| 15. Jornada | 19.11.2021 | Chernomorets Odessa | - | Dinamo Kiev | 1:6 | ||||
| 16. Jornada | 27.11.2021 | Chernomorets Odessa | - | Desna Chernigov | 0:1 | ||||
| 18. Jornada | 12.12.2021 | Chernomorets Odessa | - | Metalist 1925 Kharkiv | 2:1 |  |
Ucrania